Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641086 | 0.91 | PTGS2 (0.44) | PTGS2MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8639423 | 0.90 | PTGS2 (0.48) | PTGS2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8636816 | 0.89 | PTGS2 (0.56) | PTGS2L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL8641742 | 0.89 | PTGS2 (0.40) | PTGS2MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8639153 | 0.89 | PTGS2 (0.45) | PTGS2L3MBTL1MAPTSMN1; SMN2PTGS1 | |
| SCHEMBL7868758 | 0.85 | PTGS2 (0.53) | PTGS2MAPTSMN1; SMN2PTGS1 | |
| SCHEMBL8640523 | 0.83 | GCGR (0.45) | PTGS2MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8641218 | 0.83 | MAPT (0.46) | PTGS2ALDH1A1MAPTSMN1; SMN2PTGS1 | |
| SCHEMBL8637024 | 0.81 | PTGS2 (0.54) | PTGS2TDP1KMT2AMAPTSMN1; SMN2 | |
| Benzenesulfonamide SCHEMBL8525050 | 0.80 | PTGS2 (0.61) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |