Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868758 | 0.91 | PTGS2 (0.53) | PTGS2PTGS1MAPTSMN1; SMN2PTGER1 | |
| SCHEMBL8641218 | 0.89 | MAPT (0.46) | PTGS2PTGS1MAPTSMN1; SMN2 | |
| SCHEMBL8638222 | 0.89 | PDPK1 (0.55) | PTGS2PTGS1PDPK1SMN1; SMN2 | |
| Benzenesulfonamide SCHEMBL8525050 | 0.87 | PTGS2 (0.61) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8637024 | 0.85 | PTGS2 (0.54) | PTGS2PTGS1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL8641086 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL8639246 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1MAPTSMN1; SMN2 | |
| SCHEMBL8640455 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1MAPTSMN1; SMN2 | |
| SCHEMBL8690933 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL8640531 | 0.83 | PTGS2 (0.43) | PTGS2PTGS1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |