Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8695958 | 0.85 | ELANE (0.46) | HSD17B10FEN1ACVR1TNKSBACE1 | |
| SCHEMBL8696587 | 0.85 | HSD17B10 (0.60) | BRD4HSD17B10FEN1TNKSEGFR | |
| SCHEMBL8691820 | 0.84 | PIK3CD (0.51) | HSD17B10FEN1ACVR1PRMT5WDR77 | |
| SCHEMBL8692400 | 0.84 | TNKS (0.50) | HSD17B10FEN1TNKSMEN1 | |
| SCHEMBL8693905 | 0.84 | PDE4A (0.45) | HSD17B10FEN1ACVR1PRMT5WDR77 | |
| SCHEMBL8694011 | 0.82 | BRD4 (0.54) | BRD4HSD17B10PRKCAGSK3BMEN1 | |
| SCHEMBL8695803 | 0.81 | ELANE (0.54) | BRD4HSD17B10MEN1ELANE | |
| SCHEMBL8696634 | 0.81 | GRIN1 (0.47) | HSD17B10 | |
| SCHEMBL8693665 | 0.80 | MET (0.51) | MEN1 | |
| SCHEMBL8693990 | 0.78 | TNKS (0.49) | BRD4HSD17B10FEN1ACVR1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817670-A | RESPIRATORY SYSTEM DISORDERS, ORGAN TRANSPLANTATION, ANTITUMOR AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1998-10-06 | — | — | US | disclosed |
| EP-0779292-A1 | NOVEL NAPHTHYRIDINE DERIVATIVE AND MEDICINAL COMPOSITION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-06-18 | — | — | EP | disclosed |