Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.39 |
| ▸ | RXRA | P19793 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8693656 | 0.90 | PTGS2 (0.45) | NR1H3RXRANR1H2PTGS2PTGS1 | |
| SCHEMBL8733794 | 0.90 | PTGS2 (0.38) | PTGS2PTGS1PDPK1 | |
| SCHEMBL8688565 | 0.90 | PTGS2 (0.46) | PTGDR2NR1H3RXRANR1H2PTGS2 | |
| SCHEMBL8689245 | 0.85 | PTGS2 (0.43) | NR1H3RXRANR1H2PTGS2PTGS1 | |
| SCHEMBL8637575 | 0.84 | PTGS2 (0.52) | NR1H3RXRANR1H2PTGS2PTGS1 | |
| SCHEMBL8688934 | 0.83 | PTGS2 (0.40) | NR1H3RXRANR1H2PTGS2PTGS1 | |
| SCHEMBL8692172 | 0.83 | RXRA (0.44) | NR1H3RXRANR1H2PTGS2PTGS1 | |
| SCHEMBL8732518 | 0.83 | PTGS2 (0.44) | NR1H3RXRANR1H2PTGS2PTGS1 | |
| SCHEMBL8693449 | 0.83 | PTGS2 (0.39) | NR1H3RXRANR1H2PTGS2PTGS1 | |
| SCHEMBL8688673 | 0.82 | PTGS2 (0.43) | NR1H3RXRANR1H2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |