Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.66 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.66 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.66 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8632497 | 1.00 | CHRM1 (0.66) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| SCHEMBL6914306 | 0.91 | CHRM1 (0.80) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| Oxalic Acid SCHEMBL8625627 | 0.90 | CHRM1 (0.72) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| Fumaric Acid SCHEMBL7621680 | 0.89 | CHRM4 (0.63) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| Fumaric Acid SCHEMBL7621673 | 0.89 | CHRM4 (0.63) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| Oxalic Acid SCHEMBL7618563 | 0.88 | CHRM4 (0.71) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| SCHEMBL6915591 | 0.88 | CHRM1 (0.82) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| SCHEMBL6914990 | 0.85 | CHRM4 (0.81) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| Oxalic Acid SCHEMBL7617849 | 0.84 | CHRM1 (0.67) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| Oxalic Acid SCHEMBL7619269 | 0.83 | CHRM1 (0.71) | CHRM1CHRM4CHRM2CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996013168-A1 | METHOD FOR TREATING ANXIETY | ELI LILLY AND COMPANY (US) | 1996-05-09 | — | — | WO | claimed |
| EP-0709095-A2 | Method for treating anxiety using a tetrahydropyridine or azabicyclic oxadiazole or thiadiazole compound | ELI LILLY AND COMPANY (US) | 1996-05-01 | — | — | EP | claimed |
| US-5773452-A | ALZHEIMER'S DISEASE; COGNITION ACTIVATORS | NOVO NORDISK ALS (DK) | 1998-06-30 | — | — | US | disclosed |
| US-5750541-A | 3-(1,2,5-THIA OR OXADIAZOL-3-YL)-1,2,5,6-PYRIDINE DERIVATIVES; SCHIZOPHRENIFORM DISEASES; SIDE EFFECT REDUCTION | NOVO NORDISK A/S (DK) | 1998-05-12 | — | — | US | disclosed |
| US-5565475-A | Method of treating urinary bladder dysfunctions with 3-tetrahydropyridine derivatives | MUHLHAUSER MARK A (US) | 1996-10-15 | — | — | US | disclosed |
| US-5545638-A | USING A 3-(TETRAHYDROPYRID-3-YL-) SUBSTITUTED (OXA- OR THIA-)DIAZOLE COMPOUND | NOVO NORDISK A/S (DK) | 1996-08-13 | — | — | US | disclosed |