Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8693450 | 0.98 | PTGS2 (0.44) | PTGS2PTGS1ABCB11ALDH1A1CA12 | |
| SCHEMBL8525009 | 0.81 | PTGS2 (0.65) | PTGS2PTGS1ABCB11ALDH1A1CA12 | |
| SCHEMBL7928751 | 0.80 | PTGS2 (0.66) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL6341545 | 0.80 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1CA12 | |
| SCHEMBL8639345 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1ABCB11ALDH1A1CA12 | |
| SCHEMBL8688704 | 0.79 | PTGS2 (0.51) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8165901 | 0.79 | PTGS2 (0.62) | PTGS2PTGS1ABCB11ALDH1A1CA12 | |
| SCHEMBL8637047 | 0.78 | PTGS2 (0.63) | PTGS2PTGS1ABCB11ALDH1A1CA1 | |
| SCHEMBL8688525 | 0.78 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1CA12 | |
| SCHEMBL6341694 | 0.78 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |