Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.43 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641648 | 0.83 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL8693450 | 0.82 | PTGS2 (0.44) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL6013908 | 0.81 | PTGS2 (0.71) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8641235 | 0.80 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL8692227 | 0.80 | PTGS2 (0.44) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL7928751 | 0.79 | PTGS2 (0.66) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8637047 | 0.78 | PTGS2 (0.63) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL7773921 | 0.76 | PTGS2 (0.65) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL8525009 | 0.76 | PTGS2 (0.65) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL8637387 | 0.75 | PTGS2 (0.54) | PTGS2PTGS1ABCB11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753688-A | ANTIINFLAMMATORY | TALLEY JOHN J (US) | 1998-05-19 | — | — | US | disclosed |
| US-5510496-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5504215-A | Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation | G. D. SEARLE & CO. (US) | 1996-04-02 | — | — | US | disclosed |