Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8695608 | 0.90 | ALDH1A1 (0.47) | ALDH1A1HIF1AEPAS1S1PR1P2RX7 | |
| SCHEMBL8691239 | 0.84 | EPHX2 (0.39) | ALDH1A1P2RX7EPHX2SMN1; SMN2MEN1 | |
| SCHEMBL8691343 | 0.84 | EPHX2 (0.46) | ALDH1A1HIF1ARAB9ANPC1POLB | |
| SCHEMBL8571816 | 0.80 | EPHX2 (0.40) | ALDH1A1HIF1AEPAS1P2RX7EPHX2 | |
| SCHEMBL8694978 | 0.75 | EPHX2 (0.46) | ALDH1A1HIF1AEPAS1RAB9ANPC1 | |
| SCHEMBL8692193 | 0.74 | EPHX2 (0.41) | ALDH1A1HIF1AEPAS1P2RX7EPHX2 | |
| SCHEMBL8570979 | 0.72 | EPHX2 (0.40) | ALDH1A1P2RX7EPHX2SMN1; SMN2KMT2A | |
| SCHEMBL8839184 | 0.71 | ALDH1A1 (0.45) | ALDH1A1HIF1AEPAS1RAB9ANPC1 | |
| SCHEMBL8570549 | 0.70 | PPARG (0.45) | ALDH1A1HIF1ARAB9ANPC1P2RX7 | |
| SCHEMBL6878528 | 0.69 | KMT2A (0.51) | ALDH1A1P2RX7EPHX2TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5786379-A | Adamantyl-substituted biaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-07-28 | — | — | US | claimed |
| US-5786379-A | Adamantyl-substituted biaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-07-28 | — | — | US | disclosed |