Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.52 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968454 | 0.83 | RAB9A (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7978066 | 0.83 | RAB9A (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7968450 | 0.83 | RAB9A (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL644955 | 0.83 | BDKRB1 (0.58) | BDKRB1 | |
| SCHEMBL11023537 | 0.82 | PSEN1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL645236 | 0.82 | TSHR (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17600734 | 0.81 | BRD4 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17600737 | 0.81 | BRD4 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4344983 | 0.80 | HCRTR1 (0.52) | RAB9A | |
| SCHEMBL2977278 | 0.79 | ALDH1A1 (0.72) | FKBP1ARAB9ALMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843906-A | Meta-substituted phenylene sulphonamide derivatives | G. D. SEARLE & CO. (US) | 1998-12-01 | — | — | US | disclosed |