Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 12/20 | 0.40 |
| ▸ | DRD2 | P14416 | 10/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439267 | 0.85 | FYN (0.41) | DRD3DRD2FYNDRD4MEN1 | |
| SCHEMBL8694225 | 0.84 | PNMT (0.40) | DRD3DRD2FYNDRD4MEN1 | |
| SCHEMBL7432736 | 0.83 | DRD3 (0.57) | DRD3DRD2DRD4HTR1A | |
| SCHEMBL7433347 | 0.80 | PNMT (0.47) | — | |
| SCHEMBL8689229 | 0.78 | DRD3 (0.64) | DRD3DRD2FYNDRD4MEN1 | |
| SCHEMBL8691953 | 0.76 | DRD3 (0.42) | DRD3DRD2DRD4HTR1AADRB2 | |
| SCHEMBL7443025 | 0.71 | DRD3 (0.42) | DRD3DRD2DRD4CYP2D6HTR1A | |
| SCHEMBL1544812 | 0.69 | NR1H2 (0.42) | DRD3DRD2FYNDRD4MEN1 | |
| SCHEMBL1544809 | 0.69 | NR1H2 (0.42) | DRD3DRD2FYNDRD4MEN1 | |
| SCHEMBL7444816 | 0.69 | SLC6A4 (0.44) | DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708018-A | 2-aminoindans as selective dopamine D3 ligands | PHARMACIA & UPJOHN COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0712387-A1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004713-A1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | THE UPJOHN COMPANY (US) | 1995-02-16 | — | — | WO | disclosed |