Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449574 | 0.84 | DRD3 (0.44) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL7442254 | 0.84 | ALDH1A1 (0.46) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL7439267 | 0.81 | FYN (0.41) | — | |
| SCHEMBL8693575 | 0.80 | DRD3 (0.40) | — | |
| SCHEMBL8694225 | 0.80 | PNMT (0.40) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL7445601 | 0.79 | DRD2 (0.42) | — | |
| SCHEMBL7432736 | 0.79 | DRD3 (0.57) | — | |
| SCHEMBL3466300 | 0.78 | PNMT (0.49) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL3466297 | 0.78 | PNMT (0.49) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL12004879 | 0.76 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |