Idoxuridine

SCHEMBL8694067

COc1ccc(C(OC[C@H]2O[C@@H](n3cc(I)c(=O)[nH]c3=O)C[C@@H]2O)(c2ccccc2)c2ccccc2)cc1.O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1I

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	TK1	P04183	3/20	0.62

▸	TYMS	P04818	4/20	0.55

▸	BCHE	P06276	2/20	0.53

▸	TYMP	P19971	1/20	0.49

▸	CYP1A2	P05177	1/20	0.49

▸	CYP3A4	P08684	1/20	0.49

▸	TSHR	P16473	1/20	0.49

▸	BLM	P54132	1/20	0.49

▸	PMP22	Q01453	1/20	0.49

▸	NPSR1	Q6W5P4	1/20	0.49

▸	LMNA	P02545	2/20	0.48

▸	SMN1; SMN2	Q16637	2/20	0.48

▸	ALOX12	P18054	1/20	0.48

▸	ADRA1A	P35348	1/20	0.48

▸	TK2	O00142	1/20	0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL21133906	0.97	TYMS (0.56)	TK1TYMSBCHETYMP
SCHEMBL6294757	0.97	TYMS (0.56)	TK1TYMSBCHETYMP
SCHEMBL3599668	0.97	TYMS (0.56)	TK1TYMSBCHETYMP
SCHEMBL17123679	0.97	TYMS (0.56)	TK1TYMSBCHETYMP
SCHEMBL7541144	0.97	TYMS (0.56)	TK1TYMSBCHETYMP
SCHEMBL6294759	0.97	TYMS (0.56)	TK1TYMSBCHETYMP
SCHEMBL13255800	0.97	TYMS (0.56)	TK1TYMSBCHETYMP
SCHEMBL15235291	0.97	TYMS (0.56)	TK1TYMSBCHETYMP
SCHEMBL10692639	0.90	TK1 (0.64)	TK1TYMSBCHETYMPCYP1A2
SCHEMBL5702260	0.90	TK1 (0.64)	TK1TYMSBCHETYMPCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5843917-A	5-Fluorouracil derivatives	GLAXO WELLCOME INC. (US)	1998-12-01	—	—	US	disclosed