Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.46 |
| ▸ | XBP1 | P17861 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8694413 | 0.90 | MEN1 (0.55) | ALDH1A1MEN1KMT2ARXFP1MAPK1 | |
| SCHEMBL1315750 | 0.74 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2ARXFP1MAPK1 | |
| SCHEMBL1620208 | 0.72 | HPGD (0.53) | ALDH1A1MEN1KMT2ARXFP1MAPK1 | |
| SCHEMBL22103804 | 0.72 | MAPT (0.63) | ALDH1A1MEN1KMT2AMAPK1MAPT | |
| SCHEMBL5460419 | 0.71 | MAPK14 (0.50) | ALDH1A1MEN1KMT2ARXFP1MAPK14 | |
| SCHEMBL13756246 | 0.71 | MAPT (0.81) | MEN1KMT2AMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL2730172 | 0.71 | MAPT (0.81) | MEN1KMT2AMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL12933355 | 0.69 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ARXFP1MAPK1 | |
| SCHEMBL2645060 | 0.69 | RXFP1 (0.53) | ALDH1A1MEN1KMT2ARXFP1MAPK1 | |
| SCHEMBL2644096 | 0.69 | APOBEC3G (0.67) | ALDH1A1MEN1KMT2ARXFP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773459-A | ENZYME INHIBITORS OF KINASES AND ANTICARCINOGENIC AGENTS | SUGEN, INC. (US) | 1998-06-30 | — | — | US | disclosed |
| WO-1996040673-A1 | NOVEL UREA- AND THIOUREA-TYPE COMPOUNDS | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |