Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.63 |
| ▸ | XBP1 | P17861 | 1/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.61 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.61 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | IL18 | Q14116 | 1/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9695815 | 0.87 | MLYCD (0.67) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL3875552 | 0.87 | MLYCD (0.67) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL11054945 | 0.86 | MAPT (0.81) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL13756246 | 0.86 | MAPT (0.81) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL2730172 | 0.86 | MAPT (0.81) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL14586313 | 0.81 | MEN1 (0.62) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL5697460 | 0.81 | NPC1 (0.61) | MAPTMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL11054936 | 0.81 | MAPT (0.69) | MAPTLMNAMEN1KMT2AHTT | |
| SCHEMBL15221633 | 0.80 | KIF11 (0.68) | EPHX2ALDH1A1KIF11PANK3 | |
| SCHEMBL69655 | 0.80 | KIF11 (0.86) | MAPTLMNARAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020123675-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | DUKE UNIVERSITY (US) | 2020-06-18 | — | — | WO | disclosed |