Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8701721 | 0.83 | MAPT (0.53) | MAPTPOLBGPR119ALDH1A1CKS1B | |
| SCHEMBL31220479 | 0.82 | ALDH1A1 (0.56) | MAPTPOLBGPR119ALDH1A1CKS1B | |
| SCHEMBL110679 | 0.81 | GPR119 (0.54) | MAPTPOLBGPR119ALDH1A1CKS1B | |
| SCHEMBL7356261 | 0.81 | GPR119 (0.69) | GPR119 | |
| SCHEMBL13537760 | 0.81 | MAPT (0.46) | MAPTPOLBGPR119ALDH1A1CKS1B | |
| SCHEMBL30998109 | 0.80 | TTR (0.53) | MAPTPOLBGPR119ALDH1A1CKS1B | |
| SCHEMBL20516457 | 0.80 | POLB (0.53) | MAPTPOLBGPR119ALDH1A1CKS1B | |
| SCHEMBL671742 | 0.80 | TTR (0.53) | MAPTPOLBGPR119ALDH1A1CKS1B | |
| SCHEMBL25003007 | 0.79 | MAPT (0.72) | MAPTALDH1A1LMNATP53 | |
| SCHEMBL3436307 | 0.78 | AKR1C3 (0.57) | MAPTGPR119ALDH1A1CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780480-A | THROMBOLYTIC AGENTS, ANTICOAGULANTS | MERCK & CO., INC. (US) | 1998-07-14 | — | — | US | disclosed |