SCHEMBL8696147

SCHEMBL8696147

Cc1ccc(S(=O)(=O)O)cc1.N[C@H](/C=C/S(=O)(=O)c1ccccc1)CCc1ccccc1

nearest known ligand 0.51

Known targets — ChEMBL curated mechanism

ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CTSB P07858 4/20 0.51
CTSS P25774 2/20 0.51
CTSH P09668 2/20 0.51
CTSK P43235 2/20 0.51
CTSC P53634 2/20 0.51
ALDH1A1 P00352 1/20 0.45
CTSL P07711 4/20 0.42
CYP2D6 P10635 1/20 0.42
MAPK1 P28482 1/20 0.42
TLR9 Q9NR96 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8696155 1.00 CTSB (0.51) CTSBCTSSCTSHCTSKCTSC
SCHEMBL7357076 0.92 CTSB (0.46) CTSBCTSSCTSHCTSKCTSC
SCHEMBL7357069 0.92 CTSB (0.46) CTSBCTSSCTSHCTSKCTSC
SCHEMBL7357081 0.92 CTSB (0.46) CTSBCTSSCTSHCTSKCTSC
SCHEMBL7406161 0.86 CTSB (0.56) CTSBCTSSCTSHCTSKCTSC
SCHEMBL7406164 0.86 CTSB (0.56) CTSBCTSSCTSHCTSKCTSC
SCHEMBL7406168 0.86 CTSB (0.56) CTSBCTSSCTSHCTSKCTSC
Hydrochloric Acid SCHEMBL7362193 0.85 CTSB (0.55) CTSBCTSSCTSHCTSKCTSC
Hydrochloric Acid SCHEMBL7362196 0.85 CTSB (0.55) CTSBCTSSCTSHCTSKCTSC
Hydrochloric Acid SCHEMBL7362186 0.85 CTSB (0.55) CTSBCTSSCTSHCTSKCTSC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776718-A Reversible protease inhibitors ARRIS PHARMACEUTICAL CORPORATION (US) 1998-07-07 US disclosed