Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.41 |
| ▸ | EIF2AK1 | Q9BQI3 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 4/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374288 | 0.85 | EIF2AK3 (0.45) | EIF2AK3CYP3A4EIF2AK2EIF2AK1CYP2C9 | |
| SCHEMBL870192 | 0.81 | EIF2AK3 (0.61) | EIF2AK3CYP3A4EIF2AK1CYP2C9RIPK1 | |
| SCHEMBL868864 | 0.77 | EIF2AK3 (0.74) | EIF2AK3CYP3A4EIF2AK2EIF2AK1CYP2C9 | |
| SCHEMBL868916 | 0.77 | EIF2AK3 (0.64) | EIF2AK3CYP3A4EIF2AK2EIF2AK1CYP2C9 | |
| SCHEMBL6700286 | 0.76 | UCHL1 (0.46) | GPR119UCHL1MPOADORA1CHRNA7 | |
| SCHEMBL24651057 | 0.75 | EIF2AK3 (0.51) | EIF2AK3CYP3A4EIF2AK2EIF2AK1CYP2C9 | |
| SCHEMBL24651195 | 0.74 | SRC (0.53) | EIF2AK3CYP3A4EIF2AK2EIF2AK1CYP2C9 | |
| SCHEMBL24651196 | 0.74 | RIPK1 (0.54) | EIF2AK3CYP3A4EIF2AK2EIF2AK1CYP2C9 | |
| SCHEMBL24651206 | 0.74 | EIF2AK2 (0.52) | EIF2AK3CYP3A4EIF2AK2EIF2AK1CYP2C9 | |
| SCHEMBL24651161 | 0.72 | ABL1 (0.52) | EIF2AK3CYP3A4EIF2AK2EIF2AK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |
| US-8598156-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2013-12-03 | — | — | US | disclosed |
| US-20130018038-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2013-01-17 | — | — | US | disclosed |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018038-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885CYP3A4 1750/4885EIF2AK2 174/4885 |
| US-20120077828-A1 | CHEMICAL COMPOUNDS | BRCA1, IRS1, IGF1R | EIF2AK3 16/4885CYP3A4 1750/4885EIF2AK2 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.