Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.47 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.46 |
| ▸ | FEN1 | P39748 | 4/20 | 0.46 |
| ▸ | CA6 | P23280 | 3/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1094361 | 0.92 | CA1 (0.50) | CA1CA2CA9MAPK1ALOX5AP | |
| Pyrimidine SCHEMBL16180729 | 0.84 | CA1 (0.44) | CA1CA2CA9MAPK1ALOX5AP | |
| SCHEMBL8347239 | 0.84 | CA2 (0.58) | CA1CA2CA9MAPK1ALOX5AP | |
| SCHEMBL8697589 | 0.82 | ALOX5AP (0.47) | CA1CA2CA9MAPK1ALOX5AP | |
| SCHEMBL1080972 | 0.82 | CA2 (0.61) | CA1CA2CA9ALOX5APFEN1 | |
| SCHEMBL7974328 | 0.80 | CA1 (0.46) | CA1CA2CA9MAPK1ALOX5AP | |
| SCHEMBL1667127 | 0.78 | EDNRA (0.49) | CA1CA2CA9MAPK1ALOX5AP | |
| SCHEMBL29967288 | 0.78 | EDNRA (0.49) | CA1CA2CA9MAPK1ALOX5AP | |
| SCHEMBL12853990 | 0.77 | PTPRC (0.44) | LMNAPTPRC | |
| SCHEMBL3256397 | 0.76 | CA1 (0.73) | CA1CA2CA9MAPK1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998004260-A1 | SUBSTITUTED BIPHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-02-05 | — | — | WO | claimed |