Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 3/20 | 0.38 |
| ▸ | MMP12 | P39900 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | MMP14 | P50281 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MMP16 | P51512 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5818114 | 0.82 | CA1 (0.33) | CYP1A2PPIA | |
| SCHEMBL2587914 | 0.82 | PPIA (0.40) | CYP1A2TSHRMAPTPPIACYP2C9 | |
| SCHEMBL5917355 | 0.80 | CA1 (0.32) | CYP1A2PPIACYP2C9HPGDCYP2C19 | |
| SCHEMBL1934600 | 0.80 | ALDH1A1 (0.40) | MMP2MMP12MMP1MMP9CYP1A2 | |
| SCHEMBL114462 | 0.80 | CA1 (0.35) | CYP1A2MAPTPPIA | |
| SCHEMBL5488253 | 0.79 | CA1 (0.37) | PPIA | |
| SCHEMBL11570150 | 0.78 | AKR1B1 (0.44) | AKR1B1TDP1PTGER1PTGER4PTGER3 | |
| SCHEMBL1456494 | 0.77 | CA1 (0.33) | — | |
| SCHEMBL8084163 | 0.77 | AKR1B1 (0.43) | AKR1B1TDP1PTGER1PTGER4PTGER3 | |
| SCHEMBL3165966 | 0.74 | TTR (0.35) | CYP1A2TSHRPPIATTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359333-B2 | Efficient process for the preparation of Lapatinib and salts thereof by means of new intermediates | F.I.S.—Fabbrica Italiana Sintetiei (IT) | 2016-06-07 | — | — | US | claimed |
| US-20150322050-A1 | Efficient Process for the Preparation of Lapatinib and Salts Thereof by Means of New Intermediates | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-11-12 | — | — | US | claimed |
| US-9169236-B2 | Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates | F.I.S.-Fabbrica Italiana Sintetiei S.p.A. (IT) | 2015-10-27 | — | — | US | claimed |
| EP-2921490-A2 | PROCESS FOR THE PREPARATION OF LAPATINIB AND SALTS THEREOF BY MEANS OF NEW INTERMEDIATES | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2015-09-23 | — | — | EP | claimed |
| US-20150225376-A1 | Efficient Process for the Preparation of Lapatinib and Salts thereof by Means of New Intermediates | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-08-13 | — | — | US | claimed |
| US-9024023-B2 | Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2015-05-05 | — | — | US | claimed |
| US-20150065710-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF LAPATINIB AND SALTS THEREOF BY MEANS OF NEW INTERMEDIATES | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-03-05 | — | — | US | claimed |
| US-9359333-B2 | Efficient process for the preparation of Lapatinib and salts thereof by means of new intermediates | F.I.S.—Fabbrica Italiana Sintetiei (IT) | 2016-06-07 | — | — | US | disclosed |
| US-20150322050-A1 | Efficient Process for the Preparation of Lapatinib and Salts Thereof by Means of New Intermediates | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-11-12 | — | — | US | disclosed |
| US-9169236-B2 | Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates | F.I.S.-Fabbrica Italiana Sintetiei S.p.A. (IT) | 2015-10-27 | — | — | US | disclosed |
| EP-2921490-A2 | PROCESS FOR THE PREPARATION OF LAPATINIB AND SALTS THEREOF BY MEANS OF NEW INTERMEDIATES | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2015-09-23 | — | — | EP | disclosed |
| US-20150225376-A1 | Efficient Process for the Preparation of Lapatinib and Salts thereof by Means of New Intermediates | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-08-13 | — | — | US | disclosed |
| US-9024023-B2 | Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-20150065710-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF LAPATINIB AND SALTS THEREOF BY MEANS OF NEW INTERMEDIATES | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-03-05 | — | — | US | disclosed |
| US-5712418-A | FLUOROFORMAMIDINIUM SALTS AS FLUORINATION AGENTS TO FORM PEPTIDES | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1998-01-27 | — | — | US | disclosed |
| WO-1996004297-A1 | SYNTHESIS AND USE OF AMINO ACID FLUORIDES AS PEPTIDE COUPLING REAGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1996-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225376-A1 | Efficient Process for the Preparation of Lapatinib and Salts thereof by Means of New Intermediates | ERBB2, EGFR, ERBB4 | AKR1B1 2246/4885TDP1 2149/4885PTGER1 3342/4885 |
| US-20150065710-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF LAPATINIB AND SALTS THEREOF BY MEANS OF NEW INTERMEDIATES | ERBB2, EGFR, ERBB4 | AKR1B1 2246/4885TDP1 2149/4885PTGER1 3342/4885 |
| US-20150322050-A1 | Efficient Process for the Preparation of Lapatinib and Salts Thereof by Means of New Intermediates | ERBB2, EGFR, ERBB4 | AKR1B1 2246/4885TDP1 2149/4885PTGER1 3342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.