Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8702192 | 0.91 | CYP19A1 (0.41) | CYP19A1NPC1RAB9AHPGDKMT2A | |
| SCHEMBL8697579 | 0.88 | CYP19A1 (0.51) | CYP19A1NPC1RAB9AHPGDPOLB | |
| SCHEMBL8699069 | 0.87 | CYP19A1 (0.57) | CYP19A1NPC1RAB9A | |
| SCHEMBL8698474 | 0.84 | CYP19A1 (0.38) | CYP19A1NPC1RAB9A | |
| SCHEMBL8697545 | 0.82 | CYP19A1 (0.57) | CYP19A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL8698611 | 0.77 | CYP19A1 (0.41) | CYP19A1ATMMAOB | |
| SCHEMBL8697385 | 0.74 | CYP19A1 (0.46) | CYP19A1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL8702199 | 0.74 | CYP19A1 (0.45) | CYP19A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL8697944 | 0.72 | CYP3A4 (0.43) | CYP19A1TSHR | |
| SCHEMBL8702833 | 0.72 | CYP19A1 (0.57) | CYP19A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | claimed |
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | disclosed |