SCHEMBL8698474

SCHEMBL8698474

N#Cc1ccc(C(F)(c2cncnc2)c2ccc(-c3ccccc3)o2)cc1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 7/20 0.38
CYP3A4 P08684 1/20 0.38
CYP3A5 P20815 1/20 0.38
KIF11 P52732 1/20 0.36
MAPKAPK2 P49137 1/20 0.35
FNTA P49354 3/20 0.35
FNTB P49356 3/20 0.35
CYP11B2 P19099 1/20 0.34
PTPN5 P54829 1/20 0.34
FAAH O00519 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8702192 0.87 CYP19A1 (0.41) CYP19A1CYP3A4NPC1RAB9A
SCHEMBL8697944 0.85 CYP3A4 (0.43) CYP19A1CYP3A4CYP3A5KIF11MAPKAPK2
SCHEMBL8697579 0.85 CYP19A1 (0.51) CYP19A1MAPKAPK2NPC1RAB9A
SCHEMBL8700748 0.85 CYP3A4 (0.36) CYP19A1CYP3A4CYP3A5KIF11MAPKAPK2
SCHEMBL8697882 0.84 CYP19A1 (0.40) CYP19A1NPC1RAB9A
SCHEMBL8699069 0.84 CYP19A1 (0.57) CYP19A1CYP3A4CYP3A5NPC1RAB9A
SCHEMBL8700497 0.83 CYP19A1 (0.43) CYP19A1CYP3A4CYP3A5FNTAFNTB
SCHEMBL2351716 0.77 CYP19A1 (0.59) CYP19A1CYP3A4CYP3A5KIF11PTPN5
SCHEMBL8702170 0.76 CYP19A1 (0.43) CYP19A1CYP3A4CYP3A5KIF11FNTA
SCHEMBL8700017 0.76 CYP19A1 (0.42) CYP19A1CYP3A4CYP3A5KIF11CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998018791-A1 HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1998-05-07 WO claimed
WO-1998018791-A1 HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1998-05-07 WO disclosed