SCHEMBL8698102

SCHEMBL8698102

OC(c1ccccc1)(c1cncnc1)c1ccc(-c2ccccc2)o1

nearest known ligand 0.51

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 15/20 0.51
CYP3A4 P08684 1/20 0.41
CYP3A5 P20815 1/20 0.41
ATM Q13315 1/20 0.38
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36
CHRM5 P08912 1/20 0.36
CHRM1 P11229 1/20 0.36
CHRM3 P20309 1/20 0.36
ALOX15 P16050 1/20 0.36
TSHR P16473 1/20 0.36
CASP1 P29466 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8702833 0.91 CYP19A1 (0.57) CYP19A1CYP3A4CYP3A5
SCHEMBL8697545 0.91 CYP19A1 (0.57) CYP19A1CYP3A4CYP3A5
SCHEMBL8700484 0.91 CYP19A1 (0.57) CYP19A1CYP3A4CYP3A5
SCHEMBL8700497 0.87 CYP19A1 (0.43) CYP19A1CYP3A4CYP3A5
SCHEMBL8698122 0.81 CYP19A1 (0.44) CYP19A1CYP3A4CYP3A5
SCHEMBL8702192 0.79 CYP19A1 (0.41) CYP19A1CYP3A4ATMALOX15TSHR
SCHEMBL913343 0.77 CYP19A1 (0.79) CYP19A1CYP3A4CYP3A5ATM
SCHEMBL8697489 0.77 CYP3A4 (0.49) CYP19A1CYP3A4CYP3A5
SCHEMBL8698526 0.77 CYP3A4 (0.38) CYP19A1CYP3A4CYP3A5
SCHEMBL8697229 0.74 CYP19A1 (0.55) CYP19A1CYP3A4CYP3A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998018791-A1 HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1998-05-07 WO claimed
WO-1998018791-A1 HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) 1998-05-07 WO disclosed