Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8592294 | 0.89 | MAPT (0.47) | MAPTPOLBSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL8676073 | 0.87 | SMN1; SMN2 (0.45) | MAPTPOLBSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL4071946 | 0.85 | MAPT (0.60) | MAPTPOLBSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL8729165 | 0.84 | SMN1; SMN2 (0.42) | MAPTPOLBSMN1; SMN2ALDH1A1CYP2C9 | |
| SCHEMBL1340930 | 0.83 | MAPT (0.64) | MAPTPOLBSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL31283123 | 0.82 | ALDH1A1 (0.56) | MAPTPOLBSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL223281 | 0.82 | ALDH1A1 (0.56) | MAPTPOLBSMN1; SMN2ALDH1A1TDP1 | |
| Methane SCHEMBL7272152 | 0.81 | ALDH1A1 (0.55) | MAPTPOLBSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL153727 | 0.79 | CA1 (0.64) | MAPTPOLBALDH1A1TDP1L3MBTL1 | |
| SCHEMBL19439042 | 0.74 | MAPT (0.60) | MAPTPOLBSMN1; SMN2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998008813-A1 | COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED PYRROLIDINE LIBRARIES | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |