Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TK1 | P04183 | 1/20 | 0.41 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27904503 | 0.82 | TDP1 (0.45) | TDP1NPC1RAB9AMAPK1HIF1A | |
| SCHEMBL27904502 | 0.82 | TDP1 (0.45) | TDP1NPC1RAB9AMAPK1HIF1A | |
| SCHEMBL9997273 | 0.81 | HSD11B1 (0.50) | HSD11B1NPC1KMT2AALDH1A1LMNA | |
| SCHEMBL9997271 | 0.81 | HSD11B1 (0.50) | HSD11B1NPC1KMT2AALDH1A1LMNA | |
| SCHEMBL8078151 | 0.80 | TDP1 (0.61) | TDP1NPC1HPGDRAB9AMAPK1 | |
| SCHEMBL8522569 | 0.80 | TDP1 (0.61) | TDP1NPC1HPGDRAB9AMAPK1 | |
| SCHEMBL8522570 | 0.80 | TDP1 (0.61) | TDP1NPC1HPGDRAB9AMAPK1 | |
| SCHEMBL382618 | 0.79 | MMP1 (0.60) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL382617 | 0.79 | MMP1 (0.60) | TDP1MAPK1HIF1ASLC6A2SLC6A3 | |
| SCHEMBL11883525 | 0.78 | HSD11B1 (0.46) | HSD11B1NPC1KMT2ABCHELY96 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834468-A | ANTIINFLAMMATORY AGENTS, ANTIARTHRITIC AGENTS, ANALGESICS TREATING RHEUMATIC DISEASE, BONE DISORDER, INJURIES | ZENECA LIMITED (GB) | 1998-11-10 | — | — | US | disclosed |