Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.33 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.33 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | SDHB | P21912 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870666 | 0.94 | CFTR (0.34) | CFTRLMNAGAAPDK2MAPT | |
| SCHEMBL10072323 | 0.94 | CFTR (0.34) | CFTRLMNAGAAPDK2MAPT | |
| SCHEMBL980171 | 0.94 | PDK2 (0.39) | CFTRLMNAGAAPDK2MAPT | |
| SCHEMBL870037 | 0.90 | PDK2 (0.43) | LMNAGAAPDK2MAPTKDM4E | |
| SCHEMBL872236 | 0.89 | RXRA (0.34) | PDK2KDM4EP2RX1P2RX3P2RX4 | |
| SCHEMBL871262 | 0.89 | PDK2 (0.40) | LMNAGAAPDK2MAPTKDM4E | |
| SCHEMBL869547 | 0.89 | PDK2 (0.42) | LMNAGAAPDK2MAPTKDM4E | |
| SCHEMBL3115119 | 0.87 | MEN1 (0.36) | LMNARUVBL1P2RX1P2RX3P2RX4 | |
| SCHEMBL871063 | 0.87 | PDK2 (0.40) | CFTRLMNAGAAPDK2MAPT | |
| SCHEMBL870673 | 0.86 | CA1 (0.34) | CFTRLMNAGAAPDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619189-B1 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2020-04-15 | — | — | EP | disclosed |
| EP-2619189-B1 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2020-04-15 | — | — | EP | disclosed |
| US-10160731-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2018-12-25 | — | — | US | disclosed |
| US-20180222873-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2018-08-09 | — | — | US | disclosed |
| US-9938248-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2018-04-10 | — | — | US | disclosed |
| US-20180057468-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2018-03-01 | — | — | US | disclosed |
| US-9834523-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170197925-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2017-07-13 | — | — | US | disclosed |
| US-9611231-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-04-04 | — | — | US | disclosed |
| US-20160376242-A9 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2016-12-29 | — | — | US | disclosed |
| EP-2706053-A1 | Method for preparing 2-trifluoromethyl ketones | E. I. du Pont de Nemours and Company (US) | 2014-03-12 | — | — | EP | disclosed |
| US-8546618-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-10-01 | — | — | US | disclosed |
| US-8404649-B2 | Isoxazoline oximes as antiparasitic agents | AH USA 42 LLC (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404649-B2 | Isoxazoline oximes as antiparasitic agents | AH USA 42 LLC (US) | 2013-03-26 | — | — | US | disclosed |
| WO-2012038851-A1 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS | PFIZER INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| US-20120077765-A1 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS | PFIZER INC. (US) | 2012-03-29 | — | — | US | disclosed |
| US-20120077765-A1 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS | PFIZER INC. (US) | 2012-03-29 | — | — | US | disclosed |
| US-20110009638-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E.I. DU PONT DE NEMOURS AND COMPANY (DE) | 2011-01-13 | — | — | US | disclosed |
| EP-2260016-A2 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E. I. du Pont de Nemours and Company (US) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009126668-A2 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10160731-B2 | Method for preparing 3-trifluoromethyl chalcones | NR3C2, CYP4A11, RAE1 | CFTR 1899/4885LMNA 2654/4885GAA 4374/4885 |
| US-20180057468-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | CFTR 1899/4885LMNA 2654/4885GAA 4374/4885 |
| US-20110009638-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | CFTR 1899/4885LMNA 2654/4885GAA 4374/4885 |
| US-20170197925-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | CFTR 1899/4885LMNA 2654/4885GAA 4374/4885 |
| US-20120077765-A1 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS | CYP1A2, CYP3A7, CYP2E1 | CFTR 1430/4885LMNA 1737/4885GAA 2228/4885 |
| US-20180222873-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | CFTR 1899/4885LMNA 2654/4885GAA 4374/4885 |
| US-20160376242-A9 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | CFTR 1899/4885LMNA 2654/4885GAA 4374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.