Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ACLY | P53396 | 2/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869547 | 0.94 | PDK2 (0.42) | PDK2GAALMNAMAPTALDH1A1 | |
| SCHEMBL869874 | 0.94 | CFTR (0.37) | PDK2GAALMNAMAPTCFTR | |
| SCHEMBL23784660 | 0.91 | PDK2 (0.36) | PDK2LMNAMAPTACLYALDH1A1 | |
| SCHEMBL16692835 | 0.90 | PDK2 (0.40) | PDK2GAALMNAMAPTALDH1A1 | |
| SCHEMBL870666 | 0.90 | CFTR (0.34) | PDK2GAALMNAMAPTCFTR | |
| SCHEMBL10072323 | 0.90 | CFTR (0.34) | PDK2GAALMNAMAPTCFTR | |
| SCHEMBL869871 | 0.90 | PDK2 (0.40) | PDK2GAALMNAMAPTKDM4E | |
| SCHEMBL2780339 | 0.90 | ACLY (0.38) | PDK2GAALMNAACLYKMT2A | |
| SCHEMBL30313890 | 0.90 | ACLY (0.38) | PDK2GAALMNAACLYKMT2A | |
| SCHEMBL31366930 | 0.89 | ACLY (0.33) | GAALMNAACLYRAPGEF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063144-B1 | ANTIPARASITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-09-08 | — | — | EP | disclosed |
| EP-3063144-B1 | ANTIPARASITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-09-08 | — | — | EP | disclosed |
| EP-3733664-A1 | ANTIPARISITIC AND PESTICIDAL ISOXAZOLINE COMPOUNDS | Boehringer Ingelheim Animal Health USA Inc. (US) | 2020-11-04 | — | — | EP | disclosed |
| US-10160731-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2018-12-25 | — | — | US | disclosed |
| US-20180222873-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2018-08-09 | — | — | US | disclosed |
| US-9938248-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2018-04-10 | — | — | US | disclosed |
| US-20180057468-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2018-03-01 | — | — | US | disclosed |
| US-9834523-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170197925-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | CORTEVA AGRISCIENCE LLC | 2017-07-13 | — | — | US | disclosed |
| US-9611231-B2 | Method for preparing 3-trifluoromethyl chalcones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-04-04 | — | — | US | disclosed |
| US-8513431-B2 | Method for preparing 5-haloalkyl-4, 5-dihydroisoxazole derivatives | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-08-20 | — | — | US | disclosed |
| US-20130165663-A9 | METHOD FOR PREPARING 5-HALOALKYL-4, 5-DIHYDROISOXAZOLE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-06-27 | — | — | US | disclosed |
| US-20120277442-A1 | METHOD FOR PREPARING 5-HALOALKYL-4, 5-DIHYDROISOXAZOLE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-11-01 | — | — | US | disclosed |
| US-8217180-B2 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-07-10 | — | — | US | disclosed |
| US-20110009638-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E.I. DU PONT DE NEMOURS AND COMPANY (DE) | 2011-01-13 | — | — | US | disclosed |
| EP-2260016-A2 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E. I. du Pont de Nemours and Company (US) | 2010-12-15 | — | — | EP | disclosed |
| US-20100249424-A1 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES | E.I.DUPONT DE NEMOURS AND COMPANY (US) | 2010-09-30 | — | — | US | disclosed |
| EP-2176244-A2 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES | E. I. du Pont de Nemours and Company (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009126668-A2 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-10-15 | — | — | WO | disclosed |
| WO-2009025983-A2 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10160731-B2 | Method for preparing 3-trifluoromethyl chalcones | NR3C2, CYP4A11, RAE1 | PDK2 4164/4885GAA 4374/4885LMNA 2654/4885 |
| US-20130165663-A9 | METHOD FOR PREPARING 5-HALOALKYL-4, 5-DIHYDROISOXAZOLE DERIVATIVES | PRDX2, PRXL2A, PRDX1 | PDK2 1813/4885GAA 4401/4885LMNA 2197/4885 |
| US-20180057468-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | PDK2 4164/4885GAA 4374/4885LMNA 2654/4885 |
| US-20110009638-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | PDK2 4164/4885GAA 4374/4885LMNA 2654/4885 |
| US-20170197925-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | PDK2 4164/4885GAA 4374/4885LMNA 2654/4885 |
| US-20100249424-A1 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES | PRDX2, PRXL2A, PRDX1 | PDK2 1813/4885GAA 4401/4885LMNA 2197/4885 |
| US-20180222873-A1 | METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES | NR3C2, CYP4A11, RAE1 | PDK2 4164/4885GAA 4374/4885LMNA 2654/4885 |
| US-20120277442-A1 | METHOD FOR PREPARING 5-HALOALKYL-4, 5-DIHYDROISOXAZOLE DERIVATIVES | PRDX2, PRXL2A, PRDX1 | PDK2 1813/4885GAA 4401/4885LMNA 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.