⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31058804 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL1126384 | 0.74 | — | — | |
| SCHEMBL3402808 | 0.70 | — | — | |
| SCHEMBL8880521 | 0.70 | — | — | |
| SCHEMBL11299538 | 0.69 | HTT (0.33) | — | |
| Methane SCHEMBL2020559 | 0.68 | — | — | |
| Sulfuric Acid SCHEMBL11153071 | 0.68 | CRBN (0.41) | — | |
| SCHEMBL5656550 | 0.68 | CRBN (0.41) | — | |
| SCHEMBL8692840 | 0.67 | CRBN (0.34) | — | |
| SCHEMBL13737400 | 0.65 | TOP2A (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756667-A | Method for preparation of amino acid thiohydantoins | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 1998-05-26 | — | — | US | disclosed |
| EP-0635024-A4 | METHOD FOR PREPARATION OF AMINO ACID THIOHYDANTOINS. | GARVAN INST MED RES (AU) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995003066-A1 | SELECTIVE MODIFICATION OF THE CARBOXY THERMINUS OF A PROTEIN | PERKIN-ELMER CORPORATION (US) | 1995-02-02 | — | — | WO | disclosed |
| EP-0635024-A1 | METHOD FOR PREPARATION OF AMINO ACID THIOHYDANTOINS | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 1995-01-25 | — | — | EP | disclosed |
| WO-1993019082-A1 | METHOD FOR PREPARATION OF AMINO ACID THIOHYDANTOINS | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 1993-09-30 | — | — | WO | disclosed |
| EP-0280868-B1 | IMIDAZO- AND TRIAZOLOTHIADIAZINES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND THEIR USE AS WELL AS SOME OF THE INTERMEDIATES OBTAINED DURING THE PREPARATION OF SAID COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-06-17 | — | — | EP | disclosed |
| US-4891374-A | INFLAMMATORY RHEUMATIC DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-01-02 | — | — | US | disclosed |
| EP-0280868-A2 | Imidazo- and triazolothiadiazines, process for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-09-07 | — | — | EP | disclosed |