Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11775394 | 0.78 | CRBN (0.44) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL3402808 | 0.67 | — | — | |
| SCHEMBL8880521 | 0.67 | — | — | |
| SCHEMBL8699049 | 0.67 | — | — | |
| SCHEMBL10653236 | 0.67 | — | — | |
| Methane SCHEMBL2020559 | 0.65 | — | — | |
| SCHEMBL5656550 | 0.65 | CRBN (0.41) | CRBNTOP2ATOP2BALDH1A1MAPT | |
| SCHEMBL18814744 | 0.64 | CRBN (0.35) | CRBN | |
| SCHEMBL497739 | 0.63 | MAPT (0.39) | CRBNALDH1A1MAPT | |
| SCHEMBL3419632 | 0.63 | KMT2A (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739101-A | ADMINISTERING AN ANTICOAGULANTS | GENENTECH, INC. (US) | 1998-04-14 | — | — | US | disclosed |
| US-5589363-A | DNA encoding tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders | GENENTECH, INC. (US) | 1996-12-31 | — | — | US | disclosed |
| US-5346991-A | Tissue factor mutants useful for the treatment of myocardial infarction and coagulopathic disorders | GENENTECH, INC. (US) | 1994-09-13 | — | — | US | disclosed |