Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL930888 | 0.86 | CYP4F2 (0.50) | CYP4F2CYP4A11SMN1; SMN2MAPTNPC1 | |
| SCHEMBL931171 | 0.83 | MEN1 (0.52) | CYP4F2CYP4A11MAPTRAB9ANPSR1 | |
| SCHEMBL11655269 | 0.80 | CYP4F2 (0.50) | CYP4F2CYP4A11SMN1; SMN2MAPTNPC1 | |
| SCHEMBL931301 | 0.79 | CA12 (0.53) | CYP4F2CYP4A11SMN1; SMN2MAPTNPC1 | |
| SCHEMBL2327109 | 0.78 | F10 (0.49) | CYP4F2CYP4A11SMN1; SMN2MAPTNPC1 | |
| SCHEMBL8703734 | 0.77 | ADRB2 (0.49) | CYP4F2CYP4A11SMN1; SMN2MAPTNPC1 | |
| SCHEMBL7876761 | 0.77 | CYP4F2 (0.47) | CYP4F2CYP4A11SMN1; SMN2MAPTNPC1 | |
| SCHEMBL272958 | 0.77 | SMN1; SMN2 (0.49) | CYP4F2CYP4A11SMN1; SMN2MAPTNPC1 | |
| SCHEMBL1248647 | 0.76 | SMN1; SMN2 (0.65) | CYP4F2CYP4A11SMN1; SMN2MAPTNPC1 | |
| SCHEMBL21207905 | 0.76 | ACHE (0.46) | SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998047877-A1 | 2-BENZOYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HEPATIC PRODUCTION OF APOB-100 | GLAXO GROUP LIMITED (GB) | 1998-10-29 | — | — | WO | disclosed |