Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705189 | 0.85 | HTT (0.47) | HTTLMNAKDM4EAHRNPSR1 | |
| SCHEMBL8704322 | 0.84 | KMT2A (0.43) | HTTKDM4ENPSR1L3MBTL1MAPT | |
| SCHEMBL27360612 | 0.83 | PDE4A (0.35) | HTTLMNAKDM4EAAK1L3MBTL1 | |
| SCHEMBL8704805 | 0.82 | KDM4E (0.34) | HTTLMNAKDM4EMAPTALDH1A1 | |
| SCHEMBL8700682 | 0.81 | SLC9A1 (0.39) | — | |
| SCHEMBL8705330 | 0.81 | PSEN1 (0.37) | MEN1KMT2ACYP3A4CYP19A1 | |
| SCHEMBL8703735 | 0.79 | PDE4A (0.37) | KDM4EALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL8700673 | 0.76 | HTT (0.42) | HTTLMNAKDM4EAHRNPSR1 | |
| SCHEMBL8703990 | 0.75 | KDM4E (0.47) | LMNAKDM4ENPSR1MAPTALDH1A1 | |
| SCHEMBL8705486 | 0.74 | CMA1 (0.33) | KDM4EMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |