Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705327 | 0.91 | HTT (0.41) | HTTLMNAAAK1MAPTL3MBTL1 | |
| SCHEMBL8706213 | 0.86 | HTT (0.47) | HTTLMNAAAK1MAPTL3MBTL1 | |
| SCHEMBL8705993 | 0.85 | HTT (0.43) | HTTAAK1MAPTALDH1A1MEN1 | |
| SCHEMBL8701815 | 0.85 | HTT (0.43) | HTTLMNAAAK1MAPTALDH1A1 | |
| SCHEMBL8704442 | 0.85 | AAK1 (0.45) | HTTAAK1MAPTCD38 | |
| SCHEMBL8705466 | 0.82 | HTT (0.41) | HTTLMNAAAK1MAPTALDH1A1 | |
| SCHEMBL8704888 | 0.82 | HTT (0.41) | HTTLMNAAAK1MAPTALDH1A1 | |
| SCHEMBL8700122 | 0.82 | ALDH1A1 (0.42) | HTTLMNAAAK1MAPTALDH1A1 | |
| SCHEMBL8703295 | 0.82 | HTT (0.41) | HTTLMNAAAK1MAPTALDH1A1 | |
| SCHEMBL8700375 | 0.81 | SLC9A1 (0.38) | MAPTALDH1A1KDM4EKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |