Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6266817 | 1.00 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1LMNAMAPK1 | |
| SCHEMBL6266593 | 0.86 | ELANE (0.49) | ALDH1A1KMT2AMEN1LMNAELANE | |
| SCHEMBL6266596 | 0.86 | ELANE (0.49) | ALDH1A1KMT2AMEN1LMNAELANE | |
| SCHEMBL7301747 | 0.84 | ELANE (0.49) | ALDH1A1KMT2AMEN1LMNAMAPK1 | |
| SCHEMBL6267549 | 0.82 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1LMNAMAPK1 | |
| SCHEMBL6262918 | 0.79 | ELANE (0.40) | ALDH1A1KMT2AMEN1MAPK1ELANE | |
| SCHEMBL6262932 | 0.79 | TAS1R3 (0.50) | KMT2AMEN1LMNAELANENPC1 | |
| SCHEMBL6261618 | 0.77 | ELANE (0.49) | ALDH1A1KMT2AMEN1LMNAELANE | |
| SCHEMBL6261622 | 0.77 | ELANE (0.49) | ALDH1A1KMT2AMEN1LMNAELANE | |
| SCHEMBL7325702 | 0.75 | ELANE (0.61) | KMT2AMEN1LMNAELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843904-A | Inhibitors of interleukin-1βconverting enzyme | VERTEX PHARMACEUTICALS, INC. (US) | 1998-12-01 | — | — | US | disclosed |