Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.61 |
| ▸ | CTSL | P07711 | 4/20 | 0.54 |
| ▸ | CTSB | P07858 | 4/20 | 0.54 |
| ▸ | CTSK | P43235 | 4/20 | 0.54 |
| ▸ | CTSS | P25774 | 4/20 | 0.54 |
| ▸ | CASP3 | P42574 | 3/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | CASP7 | P55210 | 2/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323530 | 0.90 | ELANE (0.69) | ELANECTSLCTSBCTSKCTSS | |
| SCHEMBL9725896 | 0.89 | CTSK (0.53) | ELANECTSLCTSBCTSKCTSS | |
| SCHEMBL7330509 | 0.88 | CTSK (0.55) | ELANECTSLCTSBCTSKCTSS | |
| SCHEMBL7325161 | 0.88 | CTSK (0.54) | ELANECTSLCTSBCTSKCTSS | |
| SCHEMBL27278810 | 0.85 | ELANE (0.57) | ELANECTSLCTSBCTSKCTSS | |
| SCHEMBL7303462 | 0.85 | ELANE (0.57) | ELANECTSLCTSBCTSKCTSS | |
| SCHEMBL6266593 | 0.81 | ELANE (0.49) | ELANECCR1MEN1LMNAKMT2A | |
| SCHEMBL6266596 | 0.81 | ELANE (0.49) | ELANECCR1MEN1LMNAKMT2A | |
| SCHEMBL7378215 | 0.80 | CTSL (0.66) | ELANECTSLCTSBCTSKCTSS | |
| SCHEMBL7325575 | 0.79 | CTSB (0.50) | ELANECTSLCTSBCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863915-B1 | ACYLATED ENOL DERIVATIVES OF ALPHA-KETOESTERS AND ALPHA-KETOAMIDES | HOECHST MARION ROUSSEL INC (US) | 2000-02-02 | — | — | EP | disclosed |
| US-5948886-A | ELASTASE INHIBITORS OR PRODRUGS; FOR TREATMENT OF EMPHYSEMA, CYSTIC FIBROSIS, ADULT RESPIRATORY DISTRESS SYNDROME, GOUT, DISSEMINATED INTRAVASCULAR COAGULATION, RHEUMATOID ARTHRITIS, CHRONIC BRONCHITIS, INFLAMMATORY BOWEL DISEASE, SEPTICEMIA | HOECHST MARION ROUSSEL, INC. (US) | 1999-09-07 | — | — | US | disclosed |
| US-5221665-A | N-substituted amides | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1993-06-22 | — | — | US | disclosed |
| US-5166154-A | Inhibitors of human neutrophil elastase | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0369391-A2 | N-substituted amides | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 1990-05-23 | — | — | EP | disclosed |