Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8604598 | 0.85 | MEN1 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4MMP2 | |
| SCHEMBL8604601 | 0.85 | MEN1 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4MMP2 | |
| SCHEMBL8628860 | 0.79 | MEN1 (0.51) | MMP2 | |
| SCHEMBL8628866 | 0.79 | MEN1 (0.51) | MMP2 | |
| SCHEMBL8603791 | 0.76 | MEN1 (0.52) | HDAC8 | |
| SCHEMBL24572013 | 0.72 | MMP2 (0.61) | MMP2 | |
| SCHEMBL8699346 | 0.71 | SLC1A3 (0.47) | HDAC8 | |
| SCHEMBL12085491 | 0.71 | CHRNB2 (0.63) | CHRNB2CHRNB4CHRNA3CHRNA4MMP2 | |
| SCHEMBL14359605 | 0.71 | CHRNB2 (0.63) | CHRNB2CHRNB4CHRNA3CHRNA4MMP2 | |
| SCHEMBL8602144 | 0.71 | NSD2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5733880-A | ANTITUMOR AGENTS | NAPIER UNIVERSITY VENTURES LIMITED (GB) | 1998-03-31 | — | — | US | disclosed |