Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.36 |
| ▸ | CDK2 | P24941 | 5/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13536655 | 0.73 | HPGD (0.49) | HPGDALDH1A1CCNA2CDK2MAPT | |
| SCHEMBL2315805 | 0.72 | NPC1 (0.45) | HPGDALDH1A1CCNA2CDK2MAPT | |
| SCHEMBL2314406 | 0.70 | MAPT (0.49) | HPGDALDH1A1CCNA2CDK2MAPT | |
| SCHEMBL2315072 | 0.69 | CCNA2 (0.46) | HPGDALDH1A1CCNA2CDK2MAPT | |
| SCHEMBL16039880 | 0.64 | CCNA2 (0.65) | CCNA2CDK2MAPTLMNANPC1 | |
| SCHEMBL3967297 | 0.63 | ESR1 (0.50) | HPGDALDH1A1BLMLMNAESR1 | |
| SCHEMBL9426626 | 0.63 | IGFBP3 (0.43) | HPGDALDH1A1CCNA2CDK2MAPT | |
| SCHEMBL13638606 | 0.62 | MEN1 (0.67) | CHRM4ALDH1A1CCNA2CDK2MAPT | |
| SCHEMBL165773 | 0.60 | ADORA3 (0.61) | ALDH1A1MAPTLMNAPKMHTT | |
| SCHEMBL23706076 | 0.60 | BLM (0.53) | HPGDALDH1A1BLMLMNAESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712270-A | TREATING PARKINSON*S DISEASE, DOWN*S SYNDROME, AND ALZHEIMER*S DISEASE WITH COGNITION ACTIVATORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-01-27 | — | — | US | disclosed |
| US-5510478-A | TREATMENT OF NEUROLOGICAL ILLNESSES RELATED TO CHOLINERGIC DEFICIENCY; ALZHEIMERS'S DISEASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-23 | — | — | US | disclosed |