Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 10/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 10/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9989067 | 0.82 | MAOB (0.55) | TAS1R3TAS1R1MAPTLMNATSHR | |
| SCHEMBL446971 | 0.81 | TAS1R3 (0.64) | TAS1R3TAS1R1MAPTGAASMN1; SMN2 | |
| SCHEMBL10957540 | 0.80 | CA12 (0.56) | TAS1R3TAS1R1MAPTLMNATSHR | |
| SCHEMBL8696625 | 0.77 | FLT3 (0.76) | TAS1R3TAS1R1MAPTPOLBGAA | |
| SCHEMBL8696630 | 0.76 | ATM (0.59) | MAPTTSHRSMN1; SMN2HPGD | |
| SCHEMBL445130 | 0.75 | KDM4E (0.55) | TSHRSMN1; SMN2MAOBKDM4EALDH1A1 | |
| SCHEMBL6594555 | 0.74 | TAS1R3 (0.44) | TAS1R3TAS1R1MAPTLMNAGAA | |
| SCHEMBL9048693 | 0.74 | PIM1 (0.49) | TAS1R3TAS1R1MAPTPOLBMAOB | |
| SCHEMBL22906927 | 0.74 | XDH (0.43) | MAPTLMNATSHRGAAKDM4E | |
| SCHEMBL29547331 | 0.74 | XDH (0.43) | MAPTLMNATSHRGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767133-A | Secondary amines as antidiabetic and antiobesity agents | PFIZER INC. (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0703911-B1 | SECONDARY AMINES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | PFIZER (US) | 1997-07-02 | — | — | EP | disclosed |
| US-5627200-A | β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia | PFIZER INC (US) | 1997-05-06 | — | — | US | disclosed |