Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 20/20 | 0.71 |
| ▸ | TPH2 | Q8IWU9 | 11/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | CCKAR | P32238 | 2/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | MC3R | P41968 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14969175 | 0.90 | TPH1 (0.68) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL14969176 | 0.90 | TPH1 (0.68) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL14967328 | 0.89 | TPH1 (0.69) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL4463194 | 0.89 | TPH1 (0.67) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL14967333 | 0.89 | TPH1 (0.69) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL27876268 | 0.87 | TPH1 (0.84) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL869213 | 0.87 | TPH1 (0.84) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL869212 | 0.87 | TPH1 (0.84) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL14967283 | 0.86 | TPH1 (0.77) | TPH1TPH2ADORA3SLC6A2AGTR1 | |
| SCHEMBL1744285 | 0.85 | TPH1 (0.84) | TPH1TPH2ADORA3SLC6A2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077831-A1 | METHODS AND ASSAYS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | LEXICON PHARMACEUTICALS, INC. | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077831-A1 | METHODS AND ASSAYS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME | SI, HNMT, ALPI | TPH1 65/4885TPH2 50/4885ADORA3 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.