Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 6/20 | 0.48 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9343106 | 0.83 | POLB (0.50) | ATMTDP1L3MBTL1STSCA1 | |
| SCHEMBL1020413 | 0.78 | TSHR (0.56) | TDP1L3MBTL1MAPTSMN1; SMN2ALDH1A1 | |
| Guanidine SCHEMBL8705526 | 0.77 | AOC2 (0.49) | TDP1L3MBTL1MAPTALDH1A1 | |
| Guanidine SCHEMBL8703816 | 0.77 | CA12 (0.44) | TDP1CA1CA2CA9ALDH1A1 | |
| SCHEMBL27474916 | 0.77 | POLB (0.61) | CA1CA2CA9PTGS2SMN1; SMN2 | |
| SCHEMBL7339512 | 0.76 | ALDH1A1 (0.52) | CA1CA2CA9MAPTSMN1; SMN2 | |
| SCHEMBL27647867 | 0.76 | TSHR (0.54) | TDP1L3MBTL1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27668297 | 0.76 | TSHR (0.54) | TDP1L3MBTL1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL22589065 | 0.75 | PBRM1 (0.49) | TDP1PBRM1CA1CA2CA9 | |
| SCHEMBL8700256 | 0.74 | L3MBTL1 (0.51) | ATMTDP1L3MBTL1STSPBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5824691-A | CARDIOVASCULAR, CEREBROVASCULAR, RENAL DISEASES; SHOCK, ARTERIOSCLEROSIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-10-20 | — | — | US | disclosed |