Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amineptine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amineptine SCHEMBL29389410 | 0.81 | HTR2C (1.00) | HTR2CSLC6A3NR1I2OPRM1DRD3 | |
| Amineptine SCHEMBL5783484 | 0.81 | HTR2C (1.00) | HTR2CSLC6A3NR1I2OPRM1DRD3 | |
| Amineptine SCHEMBL34086 | 0.81 | HTR2C (1.00) | HTR2CSLC6A3NR1I2OPRM1DRD3 | |
| Amineptine SCHEMBL340428 | 0.80 | HTR2C (0.97) | HTR2CSLC6A3NR1I2OPRM1DRD3 | |
| Amineptine SCHEMBL362962 | 0.80 | HTR2C (0.97) | HTR2CSLC6A3NR1I2OPRM1DRD3 | |
| SCHEMBL28969679 | 0.68 | HTR2C (0.72) | HTR2CSLC6A3NR1I2OPRM1DRD3 | |
| Hexacyclonate SCHEMBL1641659 | 0.66 | USP2 (0.41) | BLMTSHRALDH1A1USP2MAPK1 | |
| Amineptine SCHEMBL28280844 | 0.65 | SLC6A3 (0.65) | HTR2CSLC6A3NR1I2OPRM1DRD3 | |
| SCHEMBL9248431 | 0.64 | HTR2C (0.64) | HTR2CSLC6A3OPRM1SMPD1KMT2A | |
| SCHEMBL390761 | 0.63 | HTR2C (0.60) | HTR2CSLC6A3KMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998022114-A1 | A METHOD FOR PROMOTING TISSUE REPAIR | DUMEX-ALPHARMA A/S (DK) | 1998-05-28 | — | — | WO | disclosed |