Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC2 | O75106 | 2/20 | 0.33 |
| ▸ | VHL | P40337 | 1/20 | 0.33 |
| ▸ | ELOC | Q15369 | 1/20 | 0.33 |
| ▸ | ELOB | Q15370 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL8707028 | 0.86 | AOC2 (0.34) | AOC2VHLELOCELOBPRSS1 | |
| SCHEMBL8700562 | 0.76 | AOC2 (0.36) | AOC2VHLELOCELOB | |
| SCHEMBL8707033 | 0.75 | AOC2 (0.35) | AOC2VHLELOCELOBPRSS1 | |
| SCHEMBL7822637 | 0.73 | CYP4F2 (0.44) | AOC2VHLELOCELOBMRGPRX4 | |
| SCHEMBL7816169 | 0.73 | SLC9A1 (0.36) | AOC2VHLELOCELOBMRGPRX4 | |
| SCHEMBL8707029 | 0.72 | AOC2 (0.39) | AOC2VHLELOCELOBPRSS1 | |
| SCHEMBL8300855 | 0.72 | AOC2 (0.43) | AOC2VHLELOCELOBPRSS1 | |
| Hydrochloric Acid SCHEMBL8702987 | 0.71 | AOC2 (0.43) | AOC2VHLELOCELOBPRSS1 | |
| SCHEMBL1388039 | 0.69 | VHL (0.40) | AOC2VHLELOCELOBMRGPRX4 | |
| Guanidine SCHEMBL8705733 | 0.68 | CA1 (0.36) | AOC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5824691-A | CARDIOVASCULAR, CEREBROVASCULAR, RENAL DISEASES; SHOCK, ARTERIOSCLEROSIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-10-20 | — | — | US | disclosed |