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Glutamine

Glutamine

SCHEMBL8700601

CSCC[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.NCC(=O)O.NCC(=O)O.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1C[C@@H](O)CN1

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ ALOX15 P16050 1/20 0.34
▸ BLM P54132 1/20 0.34
▸ PMP22 Q01453 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glutamine SCHEMBL8704396 1.00 KMT2A (0.35) KMT2AMEN1ALOX15BLMPMP22
Glutamine SCHEMBL28774549 0.88 ALOX15 (0.44) KMT2AMEN1ALOX15BLMPMP22
Glutamic Acid SCHEMBL6740018 0.85 MEN1 (0.41) KMT2AMEN1BLM
Racemethionine SCHEMBL23924542 0.85 MEN1 (0.43) KMT2AMEN1
Methionine SCHEMBL4402781 0.85 MEN1 (0.43) KMT2AMEN1
Methionine SCHEMBL3091904 0.85 MEN1 (0.43) KMT2AMEN1
Glutamine SCHEMBL29222902 0.84 ALOX15 (0.49) KMT2AALOX15BLMPMP22
Glutamine SCHEMBL1675448 0.83 ALOX15 (0.50) KMT2AALOX15BLMPMP22
Glutamine SCHEMBL5800546 0.83 ALOX15 (0.50) KMT2AALOX15BLMPMP22
Glutamine SCHEMBL4412209 0.83 ALOX15 (0.50) KMT2AALOX15BLMPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5849323-A Collagen mimetic and method of treating rheumatoid arthritis using same Braswell, A. Glenn (US) 1998-12-15 — — US claimed
US-5849323-A Collagen mimetic and method of treating rheumatoid arthritis using same Braswell, A. Glenn (US) 1998-12-15 — — US disclosed
US-5849323-A Collagen mimetic and method of treating rheumatoid arthritis using same Braswell, A. Glenn (US) 1998-12-15 — — US disclosed