Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8701084 | 0.88 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL8343101 | 0.74 | MEN1 (0.48) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL8346200 | 0.73 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL8343102 | 0.73 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL8342323 | 0.72 | LMNA (0.72) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL27890245 | 0.64 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL8341195 | 0.64 | KMT2A (0.59) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL8340571 | 0.63 | MEN1 (0.45) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL4424395 | 0.63 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL8342841 | 0.62 | KMT2A (0.65) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998033775-A1 | 2-SUBSTITUTED-1-ACYL-1,2-DIHYDROQUINOLINE DERIVATIVES TO INCREASE HDL-CHOLESTEROL LEVEL | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-06 | — | — | WO | disclosed |