Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683226 | 0.98 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2MAPTKMT2ANPC1 | |
| SCHEMBL8681182 | 0.93 | L3MBTL1 (0.48) | MAPTKMT2AL3MBTL1MAPK1NPSR1 | |
| SCHEMBL8682202 | 0.93 | L3MBTL1 (0.48) | MAPTKMT2AL3MBTL1MAPK1NPSR1 | |
| SCHEMBL8682101 | 0.93 | L3MBTL1 (0.48) | MAPTKMT2AL3MBTL1MAPK1NPSR1 | |
| SCHEMBL8682196 | 0.93 | L3MBTL1 (0.48) | MAPTKMT2AL3MBTL1MAPK1NPSR1 | |
| SCHEMBL8683103 | 0.93 | L3MBTL1 (0.48) | MAPTKMT2AL3MBTL1MAPK1NPSR1 | |
| SCHEMBL8681141 | 0.93 | L3MBTL1 (0.47) | ALDH1A1SMN1; SMN2MAPTKMT2ANPC1 | |
| SCHEMBL8681074 | 0.91 | NAAA (0.47) | ALDH1A1MAPTKMT2AL3MBTL1MAPK1 | |
| SCHEMBL8681006 | 0.91 | NAAA (0.47) | ALDH1A1MAPTKMT2AL3MBTL1MAPK1 | |
| SCHEMBL8682077 | 0.91 | NAAA (0.47) | ALDH1A1MAPTKMT2AL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844000-A1 | Use of alpha, omega-diarylalkane derivatives in the treatment and prevention of psychosis | SANKYO COMPANY LIMITED (JP) | 1998-05-27 | — | — | EP | disclosed |
| US-5556864-A | TREATMENT OF CIRCULATORY DISEASES AND PSYCHOSIS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0600717-A1 | Phenoxyalkylamines, -pyrrolidines and -piperidines for the treatment and prevention of circulatory diseases and psychosis | SANKYO COMPANY LIMITED (JP) | 1994-06-08 | — | — | EP | disclosed |