Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 10/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8502074 | 0.99 | HTT (0.60) | HTTKDM4EALDH1A1KITEGFR | |
| SCHEMBL8709202 | 0.80 | EGFR (0.65) | HTTKDM4EALDH1A1EGFRCSF1R | |
| SCHEMBL19792401 | 0.80 | KDM4E (0.62) | HTTKDM4EALDH1A1KITEGFR | |
| Hydrochloric Acid SCHEMBL8501510 | 0.79 | EGFR (0.66) | HTTKDM4EALDH1A1EGFRCSF1R | |
| SCHEMBL8708372 | 0.77 | EGFR (0.67) | EGFRCSF1RKDRABCG2KMT2A | |
| SCHEMBL5473778 | 0.77 | EGFR (0.80) | EGFRKDRCLK1ABCG2LCK | |
| Hydrochloric Acid SCHEMBL8503039 | 0.77 | EGFR (0.66) | EGFRCSF1RKDRABCG2LCK | |
| Hydrochloric Acid SCHEMBL5473795 | 0.76 | EGFR (0.80) | EGFRKDRCLK1ABCG2LCK | |
| SCHEMBL8177847 | 0.75 | MAPK1 (0.62) | HTTKDM4EEGFRCSF1RKDR | |
| SCHEMBL2259233 | 0.75 | ABCG2 (0.63) | HTTKDM4EALDH1A1EGFRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710158-A | INHIBITORS OF PROTEIN TYROSINE KINASE AND EPIDERMAL GROWTH FACTOR | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-01-20 | — | — | US | claimed |