Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.67 |
| ▸ | BRAF | P15056 | 7/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 2/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8503039 | 0.99 | EGFR (0.66) | EGFRABCG2BRAFGAAMAPT | |
| SCHEMBL8709202 | 0.83 | EGFR (0.65) | EGFRMAPTKDRMAPK14CSF1R | |
| Hydrochloric Acid SCHEMBL8501510 | 0.82 | EGFR (0.66) | EGFRMAPTKDRMAPK14CSF1R | |
| SCHEMBL7515776 | 0.81 | EGFR (0.58) | EGFRABCG2BRAFKDRMAPK14 | |
| SCHEMBL2100607 | 0.81 | EGFR (1.00) | EGFRABCG2BRAFMAPTKDR | |
| SCHEMBL8704642 | 0.77 | HTT (0.62) | EGFRABCG2KDRCSF1RKMT2A | |
| Hydrochloric Acid SCHEMBL8502074 | 0.76 | HTT (0.60) | EGFRABCG2KDRCSF1R | |
| SCHEMBL28643875 | 0.75 | EGFR (0.82) | EGFRABCG2BRAFMAPTKDR | |
| SCHEMBL8708364 | 0.74 | EGFR (0.63) | EGFRMAPTKDRMAPK14CSF1R | |
| SCHEMBL8177847 | 0.74 | MAPK1 (0.62) | EGFRKDRCSF1RERBB2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710158-A | INHIBITORS OF PROTEIN TYROSINE KINASE AND EPIDERMAL GROWTH FACTOR | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-01-20 | — | — | US | claimed |