Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | RAF1 | P04049 | 2/20 | 0.65 |
| ▸ | FBP1 | P09467 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | GMNN | O75496 | 1/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | SRC | P12931 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8501510 | 0.99 | EGFR (0.66) | EGFRMAPK1KDM4EMAPTRAF1 | |
| SCHEMBL8708364 | 0.88 | EGFR (0.63) | EGFRMAPK1KDM4EMAPTRAF1 | |
| Hydrochloric Acid SCHEMBL8503111 | 0.87 | EGFR (0.64) | EGFRMAPK1KDM4EMAPTRAF1 | |
| SCHEMBL8708372 | 0.83 | EGFR (0.67) | EGFRMAPTRAF1KMT2AMAPK14 | |
| Hydrochloric Acid SCHEMBL8503039 | 0.82 | EGFR (0.66) | EGFRMAPTRAF1MAPK14LCK | |
| SCHEMBL8704642 | 0.80 | HTT (0.62) | EGFRMAPK1KDM4EALDH1A1MEN1 | |
| Tyrphostin Ag-1478 SCHEMBL31079458 | 0.79 | EGFR (1.00) | EGFRMAPK1KDM4EMAPTRAF1 | |
| Tyrphostin Ag-1478 SCHEMBL29350062 | 0.79 | EGFR (1.00) | EGFRMAPK1KDM4EMAPTRAF1 | |
| Tyrphostin Ag-1478 SCHEMBL93838 | 0.79 | EGFR (1.00) | EGFRMAPK1KDM4EMAPTRAF1 | |
| Tyrphostin Ag-1478 SCHEMBL29483198 | 0.79 | EGFR (1.00) | EGFRMAPK1KDM4EMAPTRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710158-A | INHIBITORS OF PROTEIN TYROSINE KINASE AND EPIDERMAL GROWTH FACTOR | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-01-20 | — | — | US | claimed |