Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 1.00 |
| ▸ | DRD4 | P21917 | 16/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 0.76 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.68 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.68 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8707354 | 1.00 | DRD2 (1.00) | DRD2DRD4HTR2ATMEM97SIGMAR1 | |
| SCHEMBL8706273 | 0.94 | DRD2 (0.89) | DRD2DRD4HTR2A | |
| SCHEMBL8706523 | 0.94 | DRD2 (1.00) | DRD2DRD4HTR2A | |
| SCHEMBL8711087 | 0.93 | DRD2 (1.00) | DRD2DRD4HTR2ATMEM97SIGMAR1 | |
| SCHEMBL7218186 | 0.92 | DRD4 (0.86) | DRD2DRD4TMEM97SIGMAR1SLC6A12 | |
| SCHEMBL7694199 | 0.92 | DRD2 (0.85) | DRD2DRD4HTR2ATMEM97SIGMAR1 | |
| SCHEMBL7694198 | 0.92 | DRD2 (0.85) | DRD2DRD4HTR2ATMEM97SIGMAR1 | |
| SCHEMBL8711822 | 0.92 | DRD2 (0.85) | DRD2DRD4HTR2AMCHR1 | |
| SCHEMBL8712569 | 0.91 | DRD4 (1.00) | DRD2DRD4HTR2A | |
| SCHEMBL8712702 | 0.91 | DRD2 (1.00) | DRD2DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998037064-A1 | BENZAMIDES HAVING DOPAMINE D4 RECEPTOR AFFINITY | HOECHST MARION ROUSSEL, INC. (US) | 1998-08-27 | — | — | WO | disclosed |