Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.71 |
| ▸ | CYP26B1 | Q9NR63 | 6/20 | 0.63 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.63 |
| ▸ | RARA | P10276 | 5/20 | 0.56 |
| ▸ | RARB | P10826 | 5/20 | 0.56 |
| ▸ | RARG | P13631 | 5/20 | 0.56 |
| ▸ | RXRB | P28702 | 3/20 | 0.51 |
| ▸ | HNF4A | P41235 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8702828 | 0.88 | RARB (0.59) | RXRACYP26B1CYP26A1RARARARB | |
| SCHEMBL5894384 | 0.83 | RXRA (1.00) | RXRACYP26B1CYP26A1RARARARB | |
| SCHEMBL2240304 | 0.80 | RARB (0.76) | RXRACYP26B1CYP26A1RARARARB | |
| SCHEMBL8707221 | 0.79 | RXRA (0.74) | RXRACYP26B1CYP26A1RARARARB | |
| Hydrochloric Acid SCHEMBL9133279 | 0.79 | RARB (0.74) | RXRACYP26B1CYP26A1RARARARB | |
| SCHEMBL2808583 | 0.78 | RXRA (1.00) | RXRACYP26B1CYP26A1RARARARB | |
| Terephthalic Acid SCHEMBL27345449 | 0.78 | RARB (0.66) | RXRACYP26B1CYP26A1RARARARB | |
| SCHEMBL10563217 | 0.78 | RARB (0.70) | RXRACYP26B1CYP26A1RARARARB | |
| Terephthalic Acid SCHEMBL27259372 | 0.78 | RARB (0.66) | RXRACYP26B1CYP26A1RARARARB | |
| Terephthalic Acid SCHEMBL27346776 | 0.76 | RARB (0.67) | RXRACYP26B1CYP26A1RARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240366544-A1 | REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY THROUGH FOS/GABP IN HUMAN CANCER | UNIV JOHNS HOPKINS (US) | 2024-11-07 | — | — | US | claimed |
| US-11911356-B2 | Regulation of mutant TERT by BRAF V600E/map kinase pathway through FOS/GABP in human cancer | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-02-27 | — | — | US | claimed |
| US-20200323805-A1 | REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY THROUGH FOS/GABP IN HUMAN CANCER | THE JOHNS HOPKINS UNIVERSITY | 2020-10-15 | — | — | US | claimed |
| US-20250290152-A1 | GENETIC TRIO OF BRAF AND TERT MUTATIONS AND RS2853669TT IN PAPILLARY THYROID CANCER AGGRESSIVENESS | THE JOHNS HOPKINS UNIVERSITY | 2025-09-18 | — | — | US | disclosed |
| US-20240366544-A1 | REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY THROUGH FOS/GABP IN HUMAN CANCER | UNIV JOHNS HOPKINS (US) | 2024-11-07 | — | — | US | disclosed |
| US-11911356-B2 | Regulation of mutant TERT by BRAF V600E/map kinase pathway through FOS/GABP in human cancer | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-02-27 | — | — | US | disclosed |
| US-20200323805-A1 | REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY THROUGH FOS/GABP IN HUMAN CANCER | THE JOHNS HOPKINS UNIVERSITY | 2020-10-15 | — | — | US | disclosed |
| US-5837725-A | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors | SRI INTERNATIONAL (US) | 1998-11-17 | — | — | US | disclosed |
| WO-1995033745-A9 | NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY | — | 1996-01-18 | — | — | WO | disclosed |
| WO-1995033745-A2 | NOVEL COMPOUNDS USEFUL IN MODULATING GENE EXPRESSION OF RETINOID RESPONSIVE GENES AND/OR HAVING ANTI-AP-1 ACTIVITY | SRI INTERNATIONAL (US) | 1995-12-14 | — | — | WO | disclosed |