Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.35 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | AOC2 | O75106 | 1/20 | 0.31 |
| ▸ | P4HB | P07237 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL8705211 | 0.85 | CYP1A2 (0.40) | SLC9A1SLC9A3SLC9A2F2PRSS1 | |
| Guanidine SCHEMBL8700578 | 0.82 | PDE4A (0.43) | F2PRSS1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8707021 | 0.80 | AOC2 (0.36) | SLC9A1SLC9A3SLC9A2F2PRSS1 | |
| SCHEMBL7816615 | 0.79 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2MEN1KMT2AFBP1 | |
| Guanidine SCHEMBL8705526 | 0.78 | AOC2 (0.49) | ALDH1A1KMT2AAOC2MAPTNPC1 | |
| Guanidine SCHEMBL8707028 | 0.76 | AOC2 (0.34) | PRSS1F10ALDH1A1SMN1; SMN2AOC2 | |
| SCHEMBL7823170 | 0.76 | SLC9A1 (0.50) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8699878 | 0.75 | AOC2 (0.40) | F2PRSS1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8707025 | 0.75 | AOC2 (0.31) | F2PRSS1F10ALDH1A1AOC2 | |
| Guanidine SCHEMBL8704984 | 0.74 | KMT2A (0.38) | SLC9A1SLC9A3SLC9A2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5824691-A | CARDIOVASCULAR, CEREBROVASCULAR, RENAL DISEASES; SHOCK, ARTERIOSCLEROSIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-10-20 | — | — | US | disclosed |