Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 10/20 | 0.46 |
| ▸ | G6PD | P11413 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SHBG | P04278 | 1/20 | 0.39 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713730 | 0.83 | CYP19A1 (0.59) | CYP19A1G6PDMEN1LMNASHBG | |
| SCHEMBL5183889 | 0.80 | SRD5A1 (0.53) | CYP19A1 | |
| SCHEMBL5183886 | 0.80 | SRD5A1 (0.53) | CYP19A1 | |
| SCHEMBL4619438 | 0.78 | CYP19A1 (0.45) | CYP19A1G6PDMEN1LMNASHBG | |
| SCHEMBL8707336 | 0.74 | MBOAT4 (0.39) | CYP19A1G6PDMEN1LMNASHBG | |
| SCHEMBL6678788 | 0.74 | CYP19A1 (0.40) | CYP19A1 | |
| SCHEMBL6678791 | 0.74 | CYP19A1 (0.40) | CYP19A1 | |
| SCHEMBL28141770 | 0.72 | CYP19A1 (0.48) | CYP19A1G6PDMEN1LMNASHBG | |
| SCHEMBL23155091 | 0.71 | SHBG (0.64) | G6PDMEN1LMNASHBGSERPINA6 | |
| SCHEMBL13461623 | 0.71 | SHBG (0.64) | G6PDMEN1LMNASHBGSERPINA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880540-A1 | 17-BETA-CYCLOPROPYL(AMINO/OXY) 4-AZA STEROIDS AS ACTIVE INHIBITORS OF TESTOSTERONE 5-ALPHA-REDUCTASE AND C17-20-LYASE | HOECHST MARION ROUSSEL, INC. (US) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030069-A1 | 17-BETA-CYCLOPROPYL(AMINO/OXY) 4-AZA STEROIDS AS ACTIVE INHIBITORS OF TESTOSTERONE 5-ALPHA-REDUCTASE AND C17-20-LYASE | HOECHST MARION ROUSSEL, INC. (US) | 1997-08-21 | — | — | WO | disclosed |